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George Baxter was the patriarch of the Baxter family in Canada and was the first owner of Cataraqui Grange on the Point Road, now called Highway 15, in Kingston, Ontario. Educated at Oxford to be a Presbyterian minister, George Baxter came to Kingston from Dundee, Scotland, in 1818. He secured the position of assistant to the Headmaster of the Royal Grammar School and became Headmaster upon the retirement of the Principal. At this time, he married Grace Baillie. George and Grace had six children.

Shortly after his arrival in Kingston he bought 450 acres of land that became Cataraqui Grange. In 1820, Mr. Baxter's parents, Peter and Margaret Barbara Baxter, arrived and settled on Cataraqui Grange. Accompanying them was their daughter Isabelle, who married William Lyon Mackenzie in Montreal. After the rebellion of 1837 in Upper Canada, Mr. Baxter lost his position as Headmaster. After his dismissal, Mr. Baxter moved out to Cataraqui Grange, where he lived with his parents until the death of his father in 1837, after which time his mother moved to Toronto to live with Isabelle.

The Bowerman family emigrated from England to the United States and Canada and were a prominent family in Prince Edward County. Merton Yarwood Williams, a descendant of the Bowerman family, was a Queen's graduate (1909) and professor of Geology at the University of British Columbia.

In 1817, William Buchanan emigrated from Scotland to what is now Kemptville, Ontario. Two years later he was followed by his wife, Anne Hunter, and children. While some of William's descendants left the area, representatives of the family continued in the Kemptville region to the present day. In 1868, John Hunter, brother of Anne Buchanan, died, leaving no will. As Hunter was unmarried, the estate had to be divided between his nine nieces and nephews. There followed a relatively long correspondence between persons in England and the Buchanans in Kemptville, as the estate settlement dragged on. In 1930, a rumor started that a William Buchanan of Kemptville had entailed his estate for 99 years after his death. As of 1930 the 99 years had apparently elapsed and the estate, amounting to some $850.000 was to be divided among living descendants. The papers include some correspondence on this issue.

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The Hon. Richard Cartwright (1759-1815) was born in Albany, New York. His early years were spent in study, until the outbreak of the American Revolution. In 1777 he left for Canada where he was appointed secretary to Colonel Butler of the Queen's Rangers. He served in that capacity for two years and in 1780 formed a partnership with the Hon. Robert Hamilton. Together they became two of the foremost merchants in Upper Canada. In 1784 the partnership was legally dissolved but they continued to cooperate closely in business affairs and became firmly established in a wholesale mercantile and shipping trade. In 1788, Cartwright was appointed judge of the Court of Common Pleas for the district of Mecklenburgh and in 1792 became a member of the Legislative Council of Upper Canada. During the War of 1812, he was commandant of the Midland District.

James Cartwright (1786-1811) was the eldest son of Richard and Magdalen Cartwright. After being educated by the Reverend John Strachen, James was sent to Quebec in 1803 for legal training and to learn French. In 1811, James and brother Richard Jr. took a journey to the Bahamas, Cuba and the south-eastern United States hoping to improve Richard's health. Richard died during the trip. James died later in 1811.

John Solomon Cartwright (1804-1845) was born in Kingston, Upper Canada, son of Richard Cartwright and twin brother of Rev. Robert Cartwright. He studied law in York (Toronto) and later at Lincoln's Inn, London. In 1831 he became president of the Commercial Bank of Kingston. In 1836 he was elected to the Legislative Assembly of Upper Canada and in 1841 he was elected to the Legislative Assembly of United Canada for Lennox and Addington. Offered the position of Solicitor General for Governor General Sir James Bagot in 1842, he declined.

Sir Richard Cartwright (1835-1912) was born in Kingston, the son of Rev. Robert David Cartwright and the grandson of the Hon. Richard Cartwright. He was educated at Trinity College, Dublin, and upon returning to Canada became president of the Commercial Bank of the Midland District. In 1863 he was elected to the Legislative Assembly as a Conservative and in 1867 was elected to the Canadian House of Commons. He "crossed the floor" to join the ranks of the Liberal Party and was Minister of Finance in the Alexander Mackenzie administration from 1873 to 1878. In 1896 he became Minister of Trade and Commerce in the Laurier administration and in 1904 was appointed to the Senate, a post he held until his death.

The family includes W.H. Coombs, a teacher, and A.A. Coombs, a daguerreotype photographer.

Agnes Douglas Craine, one of the earliest women graduates of Queen's in medicine, was born in 1862 in Smith's Falls, the daughter of John Joseph Craine and Agnes Muir Craine. She entered the Women's Medical College, associated with Queen's University, in 1884 and received the degrees of M.D and C.M. in 1888. She then went to Europe for post-graduate work, studying in London, Paris, Berlin and Vienna, before establishing her practice at Smith's Falls. Dr. Craine was a direct descendant of the first settlers to land at Chateauguay, Québec, and there are records of Craines in the New Haven colony as early as 1637.

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The Fairfields were a well-known United Empire Loyalist family. William Fairfield, the first settler, chose the location of the Fairfield homestead near where Amherstview is today when he came to Canada from Vermont in 1784.William Senior was the father of six sons and six daughters, of whom three were born at the Fairfield homestead. Stephen Fairfield, the fifth son of William Senior, and his son and grandson were the only descendants who stayed on the original homestead. During the war of 1812, some interesting family ties provided correspondence between Major Brown of Brownsville, N.Y., husband of Clara, William Senior's youngest daughter, and brother of General Brown who commanded the American forces, and his Canadian in-laws. About 1840, Stephen, now "land-poor" and without Negro help, turned his house into a tavern run by tenants. With an increase in his personal fortune the old house was restored to its original use.